Muscle precursor cells injected into irradiated mdx mouse muscle persist after serial injury
Identifieur interne : 000750 ( Main/Exploration ); précédent : 000749; suivant : 000751Muscle precursor cells injected into irradiated mdx mouse muscle persist after serial injury
Auteurs : Jacqueline G. Gross [Royaume-Uni] ; Jennifer E. Morgan [Royaume-Uni]Source :
- Muscle & Nerve [ 0148-639X ] ; 1999-02.
English descriptors
- Teeft :
- Adult mouse muscle, Australian tiger snake, Best time, Cell biology, Cell implantation, Cervical dislocation, Chick embryo, Clone, Constructive criticism, Control muscles, Cryostat sections, Degeneration, Different categories, Donor, Donor cells, Donor origin, Enzymatic disaggregation, Enzymatically disaggregated, Experimental plan, February, Fiber, Final concentration, Form muscle, Further treatment, Hamilton syringe, Heterodimer, Horse serum, Host muscle, Immature fibers, Immunostain, Implantation, Individual fibers, Injection, Intramuscular injection, John wiley sons, Large numbers, Last notexin injection, Liquid nitrogen, Mature fibers, Mature muscle, Mature muscle fibers, Mouse, Mouse muscle, Mouse muscles, Much muscle, Muscle, Muscle degeneration, Muscle fibers, Muscle nerve, Muscle nerve february, Muscle precursor cells, Muscle regeneration, Muscle satellite cells, Muscular dystrophy, Myogenic, Myogenic cells, Myogenic clones, Neonatal myosin, None muscle, Notexin, Notexin administration, Notexin injection, Notexin injections, Notexin injury, Notexin treatment, Partridge, Persistent muscle precursor cells, Persistent muscle precursor cells muscle nerve february, Positive fibers, Precursor, Precursor cells, Proc natl acad, Proliferative capacity, Regenerated, Regenerated fibers, Regeneration, Right legs, Satellite cells, Serial injections, Skeletal muscle, Skeletal muscle regeneration, Sodium deoxycholate, Soleus muscles, Third injection, Tissue culture, Tissue culture medium, Undifferentiated, Variable numbers.
Abstract
Muscle of donor origin was formed after implantation of H‐2Kb‐tsA58 muscle precursor cells (mpc) into irradiated mdx nu/nu mouse muscles. A series of injections of the myotoxin, notexin, which destroys mature muscle fibers but spares muscle precursor cells and other tissues, was made into the mpc‐injected muscles, leaving time for regeneration to occur between each injection. New muscle fibers of donor origin were formed after up to four notexin treatments, providing evidence that some of the implanted mpc reentered an undifferentiated, quiescent, stem cell‐like state and were capable of myogenesis after further injuries to the muscle. A similar model could be used to assay whether preparations of human mpc contain long‐lasting precursor cells, prior to their implantation into patients. In control mdx muscles, which had been irradiated, injected with tissue culture medium, and given three notexin injections, regeneration also occurred, indicating that radiation‐resistant mpc were present, presumably within the treated muscle. © 1999 John Wiley & Sons, Inc. Muscle Nerve 22: 174–185, 1999
Url:
DOI: 10.1002/(SICI)1097-4598(199902)22:2<174::AID-MUS5>3.0.CO;2-S
Affiliations:
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Gross</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Muscle Cell Biology, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London, W12 ONN</wicri:cityArea></affiliation></author><author><name sortKey="Morgan, Jennifer E" sort="Morgan, Jennifer E" uniqKey="Morgan J" first="Jennifer E." last="Morgan">Jennifer E. Morgan</name><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Muscle Cell Biology, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London, W12 ONN</wicri:cityArea></affiliation><affiliation wicri:level="2"><country>Royaume-Uni</country><placeName><region type="country">Angleterre</region></placeName><wicri:cityArea>Correspondence address: Muscle Cell Biology, MRC Clinical Sciences Centre, Imperial College School of Medicine, Hammersmith Hospital, Du Cane Road, London, W12 ONN</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Muscle & Nerve</title><title level="j" type="alt">MUSCLE AND NERVE</title><idno type="ISSN">0148-639X</idno><idno type="eISSN">1097-4598</idno><imprint><biblScope unit="vol">22</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="174">174</biblScope><biblScope unit="page" to="185">185</biblScope><biblScope unit="page-count">12</biblScope><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>New York</pubPlace><date type="published" when="1999-02">1999-02</date></imprint><idno type="ISSN">0148-639X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0148-639X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Adult mouse muscle</term><term>Australian tiger snake</term><term>Best time</term><term>Cell biology</term><term>Cell implantation</term><term>Cervical dislocation</term><term>Chick embryo</term><term>Clone</term><term>Constructive criticism</term><term>Control muscles</term><term>Cryostat sections</term><term>Degeneration</term><term>Different categories</term><term>Donor</term><term>Donor cells</term><term>Donor origin</term><term>Enzymatic disaggregation</term><term>Enzymatically disaggregated</term><term>Experimental plan</term><term>February</term><term>Fiber</term><term>Final concentration</term><term>Form muscle</term><term>Further treatment</term><term>Hamilton syringe</term><term>Heterodimer</term><term>Horse serum</term><term>Host muscle</term><term>Immature fibers</term><term>Immunostain</term><term>Implantation</term><term>Individual fibers</term><term>Injection</term><term>Intramuscular injection</term><term>John wiley sons</term><term>Large numbers</term><term>Last notexin injection</term><term>Liquid nitrogen</term><term>Mature fibers</term><term>Mature muscle</term><term>Mature muscle fibers</term><term>Mouse</term><term>Mouse muscle</term><term>Mouse muscles</term><term>Much muscle</term><term>Muscle</term><term>Muscle degeneration</term><term>Muscle fibers</term><term>Muscle nerve</term><term>Muscle nerve february</term><term>Muscle precursor cells</term><term>Muscle regeneration</term><term>Muscle satellite cells</term><term>Muscular dystrophy</term><term>Myogenic</term><term>Myogenic cells</term><term>Myogenic clones</term><term>Neonatal myosin</term><term>None muscle</term><term>Notexin</term><term>Notexin administration</term><term>Notexin injection</term><term>Notexin injections</term><term>Notexin injury</term><term>Notexin treatment</term><term>Partridge</term><term>Persistent muscle precursor cells</term><term>Persistent muscle precursor cells muscle nerve february</term><term>Positive fibers</term><term>Precursor</term><term>Precursor cells</term><term>Proc natl acad</term><term>Proliferative capacity</term><term>Regenerated</term><term>Regenerated fibers</term><term>Regeneration</term><term>Right legs</term><term>Satellite cells</term><term>Serial injections</term><term>Skeletal muscle</term><term>Skeletal muscle regeneration</term><term>Sodium deoxycholate</term><term>Soleus muscles</term><term>Third injection</term><term>Tissue culture</term><term>Tissue culture medium</term><term>Undifferentiated</term><term>Variable numbers</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Muscle of donor origin was formed after implantation of H‐2Kb‐tsA58 muscle precursor cells (mpc) into irradiated mdx nu/nu mouse muscles. A series of injections of the myotoxin, notexin, which destroys mature muscle fibers but spares muscle precursor cells and other tissues, was made into the mpc‐injected muscles, leaving time for regeneration to occur between each injection. New muscle fibers of donor origin were formed after up to four notexin treatments, providing evidence that some of the implanted mpc reentered an undifferentiated, quiescent, stem cell‐like state and were capable of myogenesis after further injuries to the muscle. A similar model could be used to assay whether preparations of human mpc contain long‐lasting precursor cells, prior to their implantation into patients. In control mdx muscles, which had been irradiated, injected with tissue culture medium, and given three notexin injections, regeneration also occurred, indicating that radiation‐resistant mpc were present, presumably within the treated muscle. © 1999 John Wiley & Sons, Inc. Muscle Nerve 22: 174–185, 1999</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li></region></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Gross, Jacqueline G" sort="Gross, Jacqueline G" uniqKey="Gross J" first="Jacqueline G." last="Gross">Jacqueline G. Gross</name></region><name sortKey="Morgan, Jennifer E" sort="Morgan, Jennifer E" uniqKey="Morgan J" first="Jennifer E." last="Morgan">Jennifer E. Morgan</name><name sortKey="Morgan, Jennifer E" sort="Morgan, Jennifer E" uniqKey="Morgan J" first="Jennifer E." last="Morgan">Jennifer E. Morgan</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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